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TCL1 (ABT378) mouse mAb

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说明书下载
货号: PH0120
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
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靶点: TCL1
应用: IHC,ELISA
反应性 : Human,
宿主物种 : Mouse
MW(CalcμLated) : 13kD
MW(Observed): 13kD
同种型-Isotype : IgG2b,Kappa

隐藏域元素占位

详细信息

推荐稀释比 : IHC 1:200-400;ELISA 1:500-5000
组成 : PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺 : The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
克隆性 : Monoclonal
克隆号 : ABT378

抗原&靶点信息

特异性 : The antibody can specifically recognize human TCL1 protein.
基因名称 : TCL1A TCL1
蛋白名称 : TCL1
别名 : T-cell leukemia/lymphoma protein 1A;Oncogene TCL-1;Oncogene TCL1;Protein p14 TCL1;

数据库链接:

Organism

基因 ID

SwissProt

背景:

Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010],

细胞定位 : Cytoplasmic, Nuclear

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