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p95/NBS1 (Phospho Ser343) rabbit pAb

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说明书下载
货号: PF0508
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
+

所属分类:


靶点: p95/NBS1
应用: WB
反应性 : Human,Mouse
宿主物种 : Rabbit
MW(Observed): 85kD
同种型-Isotype : IgG

隐藏域元素占位

详细信息

修饰-Modification : Phospho
推荐稀释比 : WB 1:1000-2000
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Polyclonal

抗原&靶点信息

特异性 : This antibody detects endogenous levels of Human Mouse p95 or NBS1 (phospho-Ser343)
基因名称 : NBN NBS NBS1 P95
蛋白名称 : p95/NBS1 (Ser343)
别名 : Nibrin;Cell cycle regulatory protein p95;Nijmegen breakage syndrome protein 1;

数据库链接:

Organism

基因 ID

SwissProt

背景:

Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. [provided by RefSeq, Jul 2008],

细胞定位 : Nucleus . Nucleus, PML body . Chromosome, telomere . Chromosome . Localizes to discrete nuclear foci after treatment with genotoxic agents (PubMed:26438602, PubMed:10783165, PubMed:26215093). Acetylation of 'Lys-5' of histone H2AX (H2AXK5ac) promotes NBN/NBS1 assembly at the sites of DNA damage (PubMed:26438602). .

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