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修饰-Modification ： Phospho
推荐稀释比 ： WB 1:500-2000;IHC 1:50-200
组成 ： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺 ： The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存 ： -15°C to -25°C/1 year(Do not lower than -25°C
浓度 ： 1 mg/ml
克隆性 ： Polyclonal
抗原&靶点信息
特异性 ： This antibody detects endogenous levels of RBBP8 (Phospho Ser664) Rabbit pAb at Human, Mouse,Rat
基因名称 ： RBBP8 CTIP
蛋白名称 ： DNA endonuclease RBBP8 (CtBP-interacting protein) (CtIP) (Retinoblastoma-binding protein 8) (RBBP-8) (Retinoblastoma-interacting protein and myosin-like) (RIM) (Sporulation in the absence of SPO11 protein 2 homolog) (SAE2)
别名 ： DNA endonuclease RBBP8;CtBP-interacting protein;CtIP;Retinoblastoma-binding protein 8;RBBP-8;Retinoblastoma-interacting protein and myosin-like;RIM;Sporulation in the absence of SPO11 protein 2 homolog;SAE2;
背景：
RB binding protein 8, endonuclease(RBBP8) Homo sapiens The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008],
细胞定位 ： Nucleus . Chromosome . Associates with sites of DNA damage in S/G2 phase (PubMed:10764811, PubMed:25349192). Ubiquitinated RBBP8 binds to chromatin following DNA damage (PubMed:16818604). .
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