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货号: PF0461
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
所属分类:
靶点: SF3B1
应用: WB,IHC
反应性 : Human,Mouse
宿主物种 : Rabbit
MW(Observed): 145kD
同种型-Isotype : IgG
隐藏域元素占位
详细信息
修饰-Modification : Phospho
推荐稀释比 : WB 1:500-2000;IHC 1:50-300
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Polyclonal
抗原&靶点信息
特异性 : This antibody detects endogenous levels of Human Mouse SF3B1 (phospho-Thr313)
基因名称 : SF3B1 SAP155
蛋白名称 : SF3B1 (Thr313)
别名 : SF3B1;SAP155;Splicing factor 3B subunit 1;Pre-mRNA-splicing factor SF3b 155 kDa subunit;SF3b155;Spliceosome-associated protein 155;SAP 155
背景:
This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],


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