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详细信息
推荐稀释比 ： IHC: 100-300;WB 1:1000;IF 1:50-200
组成 ： PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
纯化工艺 ： The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
储存 ： -15°C to -25°C/1 year(Do not lower than -25°C
克隆性 ： Monoclonal
克隆号 ： 1B10
抗原&靶点信息
特异性 ： The antibody detects endogenous ERCC1 proteins.
基因名称 ： ERCC1
蛋白名称 ： DNA excision repair protein ERCC-1
别名 ： ERCC1;DNA excision repair protein ERCC-1
背景：
The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein ge
细胞定位 ： [Isoform 1]: Nucleus .; [Isoform 2]: Cytoplasm . Nucleus .; [Isoform 3]: Nucleus .; [Isoform 4]: Nucleus .
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