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货号: PH1305
货期: 一周
价格: 100μL/2200
所属分类：
靶点: HP1γ
应用： WB,IF,IP,IHC
反应性 ： Mouse,Human,Monkey,Hamster,Rat
宿主物种 ： Mouse
MW(Observed)： 22kD
隐藏域元素占位
详细信息
推荐稀释比 ： WB 1:1000;ICC 1:200;IF 1:50-200
组成 ： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 ： The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
储存 ： -15°C to -25°C/1 year(Do not lower than -25°C
克隆性 ： Monoclonal
抗原&靶点信息
特异性 ： This antibody detects endogenous levels of HP1-gamma and does not cross-react with related proteins.
基因名称 ： cbx3
别名 ： CBX 3;CBX3;CBX3_HUMAN;Chromobox homolog 3;HP1 gamma homolog, Drosophila;Chromobox homolog 3;Chromobox protein homolog 3;GAMMA;HECH;Heterochromatin like protein 1;Heterochromatin protein 1 homolog gamma;Heterochromatin protein HP1 gamma;HP1 gamma;HP1 gamma homolog;HP1Hs gamma;Modifier 2 protein.
背景：
At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.[provided by RefSeq, Mar 2011],
细胞定位 ： Nucleus . Associates with euchromatin and is largely excluded from constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis (Potential). .
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