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推荐稀释比 ： Optimal working dilutions should be determined experimentally by the investigator;Suggested starting dilutions are as follows:IHC 1:200;IF 1:200.
组成 ： Liquid in PBS, pH 7.4, containing 0.02% sodium azide as preservative and 50% Glycerol.
纯化工艺 ： The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
储存 ： Stable for one year at -15°C to -25°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. Store in dark.
浓度 ： 1mg/ml
克隆性 ： Monoclonal
克隆号 ： 12D10
抗原&靶点信息
特异性 ： PCNA Monoclonal Antibody(12D10) Cy3 Conjugated specially designed for your Immunofluorescence analysis.
基因名称 ： PCNA
蛋白名称 ： Proliferating cell nuclear antigen
别名 ： PCNA;Proliferating cell nuclear antigen;PCNA;Cyclin
背景：
The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008],
细胞定位 ： Nucleus . Colocalizes with CREBBP, EP300 and POLD1 to sites of DNA damage (PubMed:24939902). Forms nuclear foci representing sites of ongoing DNA replication and vary in morphology and number during S phase (PubMed:15543136). Co-localizes with SMARCA5/SNF2H and BAZ1B/WSTF at replication foci during S phase (PubMed:15543136). Together with APEX2, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents. .
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