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货号: PH1361
货期: 一周
价格: 100μL/2200
所属分类:
靶点: Mi2-α
应用: WB,IHC,IF,Flow Cyt
反应性 : Human,Mouse,Rat,Bovine,Dog,Pig
宿主物种 : Mouse
MW(CalcμLated) : 227kD
隐藏域元素占位
详细信息
推荐稀释比 : WB 1:1000-1:2000;IHC 1:500-1:1000;IF 1:100-1:500;Flow Cyt 1:100-1:200;Not yet tested in other applications.
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : Affinity purification
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
克隆性 : Monoclonal
抗原&靶点信息
特异性 : Mi2-α Monoclonal Antibody detects endogenous levels of Mi2-α protein.
基因名称 : CHD3
蛋白名称 : Chromodomain-helicase-DNA-binding protein 3
别名 : CHD3;Chromodomain-helicase-DNA-binding protein 3;CHD-3;ATP-dependent helicase CHD3;Mi-2 autoantigen 240 kDa protein;Mi2-alpha;Zinc finger helicase;hZFH
背景:
This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008],


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