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RUBIC rabbit pAb

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说明书下载
货号: PG5440
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
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所属分类:


靶点: RUBIC
应用: WB
反应性 : Human,Mouse
宿主物种 : Rabbit
MW(Observed): 105kD
同种型-Isotype : IgG

隐藏域元素占位

详细信息

推荐稀释比 : WB 1:500-2000
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Polyclonal

抗原&靶点信息

特异性 : This antibody detects endogenous levels of RUBIC at Human/Mouse
基因名称 : KIAA0226
蛋白名称 : RUBIC
别名 : Run domain Beclin-1 interacting and cystein-rich containing protein;Rubicon;Beclin-1 associated RUN domain containing protein;Baron;

数据库链接:

Organism

基因 ID

SwissProt

背景:

The protein encoded by this gene is a negative regulator of autophagy and endocytic trafficking and controls endosome maturation. This protein contains two conserved domains, an N-terminal RUN domain and a C-terminal DUF4206 domain. The RUN domain is involved in Ras-like GTPase signaling, and the DUF4206 domain contains a diacylglycerol (DAG) binding-like motif. Mutation in this gene results in deletion of the DAG binding-like motif and causes a recessive ataxia. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014],

细胞定位 : Late endosome . Lysosome . Early endosome . Predominantly located in late endosomes/lysosomes, only partially detected in early endosome and not at all in the Golgi apparatus.

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