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货号: PG6549
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
所属分类:
靶点: PHB2
应用: WB,ELISA
反应性 : Human,Rat,Mouse
宿主物种 : Rabbit
MW(Observed): 32kD
同种型-Isotype : IgG
隐藏域元素占位
详细信息
推荐稀释比 : WB 1:500-2000;ELISA 1:5000-20000
组成 : PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺 : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Polyclonal
抗原&靶点信息
特异性 : PHB2 Polyclonal Antibody detects endogenous levels of protein.
基因名称 : PHB2 BAP REA
蛋白名称 : Prohibitin-2 (B-cell receptor-associated protein BAP37) (D-prohibitin) (Repressor of estrogen receptor activity)
背景:
developmental stage:Levels of expression in fibroblasts decrease heterogeneously during cellular aging.,function:Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging.,induction:Expression increases approximately 3-fold upon entry into G1 phase compared to other phases of the cell cycle. Also induced following inhibition of mitochondrial protein synthesis by thiamphenicol.,similarity:Belongs to the prohibitin family.,subcellular location:Also cytoplasmic and nuclear.,subunit:Interacts with PHB, ESR1, HDAC1 and HDAC5.,


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