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推荐稀释比 ： WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:40000;IF 1:50-200
组成 ： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 ： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 ： -15°C to -25°C/1 year(Do not lower than -25°C
浓度 ： 1 mg/ml
克隆性 ： Polyclonal
抗原&靶点信息
特异性 ： The antibody detects endogenous BAI1 protein
基因名称 ： BAI1
蛋白名称 ： Brain-specific angiogenesis inhibitor 1
别名 ： BAI1;Brain-specific angiogenesis inhibitor 1
背景：
Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family,
细胞定位 ： Cell membrane ; Multi-pass membrane protein . Cell projection, phagocytic cup . Cell junction, focal adhesion . Cell projection, dendritic spine . Cell junction, synapse, postsynaptic density .; [Vasculostatin-120]: Secreted .; [Vasculostatin-40]: Secreted .
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