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推荐稀释比 ： ELISA 1:5000-100000
组成 ： Phosphate-buffered solution
来源 ： Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell
纯化工艺 ： Recombinant Expression and Affinity purified
储存 ： -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
浓度 ： Please check the information on the tube
克隆性 ： Monoclonal
克隆号 ： PN0578
抗原&靶点信息
特异性 ： This recombinant monoclonal antibody can detects endogenous levels of CD366/TIM-3 protein.
基因名称 ： HAVCR2 TIM3 TIMD3
蛋白名称 ： Cadherin-2 (CDw325) (Neural cadherin) (N-cadherin) (CD antigen CD325)
别名 ： CADH2_HUMAN antibody;Cadherin 2 antibody;Cadherin 2 N cadherin neuronal antibody;Cadherin 2 type 1 antibody;Cadherin 2 type 1 N cadherin neuronal antibody;Cadherin 2;type 1;N-cadherin;neuronal;antibody;Cadherin-2 antibody;Cadherin2 antibody;Calcium dependent adhesion protein neuronal antibody;CD325 antibody;CD325 antigen antibody;CDH2 antibody;CDHN antibody;CDw325 antibody;CDw325 antigen antibody;N cadherin 1 antibody;N-cadherin antibody;NCAD antibody;Neural cadherin antibody;OTTHUMP00000066304 antibody;OTTHUMP00000067378 antibody;CD325 nanobody;
背景：
The protein encoded byThis gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases.This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011]
细胞定位 ： Membrane ; Single-pass type I membrane protein . Cell junction . Cell membrane . Localizes to the immunological synapse between CD8+ T-cells and target cells. .
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