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货号: PH0856
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
靶点: CD16
应用: WB,IHC,IF,
反应性 : Human
宿主物种 : Mouse
MW(Observed): 45kD
隐藏域元素占位
详细信息
推荐稀释比 : WB 1:1000;IHC 1:50-300;IF 1:50-200
组成 : PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
纯化工艺 : The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
克隆性 : Monoclonal
克隆号 : Q32
抗原&靶点信息
特异性 : The antibody detects endogenous CD16 protein.
基因名称 : FCGR3A/FCGR3B
蛋白名称 : Low affinity immunoglobulin gamma Fc region receptor III-A/Low affinity immunoglobulin gamma Fc region receptor III-B
数据库链接:
背景:
This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq,


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