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Lsk Monoclonal Antibody

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说明书下载
货号: PH1565
货期: 一周
价格: 100μL/2200
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靶点: Lsk
应用: WB,Flow Cyt,ELISA
反应性 : Human
宿主物种 : Mouse
MW(CalcμLated) : 56kD

隐藏域元素占位

详细信息

推荐稀释比 : WB 1:500-1:2000;Flow Cyt 1:200-1:400;ELISA 1:10000;Not yet tested in other applications.
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : Affinity purification
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
克隆性 : Monoclonal

抗原&靶点信息

特异性 : Lsk Monoclonal Antibody detects endogenous levels of Lsk protein.
基因名称 : MATK
蛋白名称 : Megakaryocyte-associated tyrosine-protein kinase
别名 : MATK;CTK;HYL;Megakaryocyte-associated tyrosine-protein kinase;CSK homologous kinase;CHK;Hematopoietic consensus tyrosine-lacking kinase;Protein kinase HYL;Tyrosine-protein kinase CTK

数据库链接:

Organism

基因 ID

SwissProt

Mouse
背景:

The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008],

细胞定位 : Cytoplasm . Membrane . In platelets, 90% of MATK localizes to the membrane fraction, and translocates to the cytoskeleton upon thrombin stimulation.

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