产品服务
信号通路
详细信息
推荐稀释比 ： ELISA 1:5000-100000;Flow Cyt 1-2μg/Test
组成 ： Phosphate-buffered solution
来源 ： Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell
纯化工艺 ： Recombinant Expression and Affinity purified
储存 ： -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
浓度 ： Please check the information on the tube
克隆性 ： Monoclonal
克隆号 ： PN0656
抗原&靶点信息
特异性 ： This recombinant monoclonal antibody can detects endogenous levels of CD33 protein.
基因名称 ： CD33 SIGLEC3
蛋白名称 ： CD82 antigen (C33 antigen) (IA4) (Inducible membrane protein R2) (Metastasis suppressor Kangai-1) (Suppressor of tumorigenicity 6 protein) (Tetraspanin-27) (Tspan-27) (CD antigen CD82)
别名 ： 4F9 antibody;Antigen detected by monoclonal and antibody IA4 antibody;C33 antibody;C33 antigen antibody;CD 82 antibody;CD82 antibody;CD82 antigen antibody;CD82 molecule antibody;CD82_HUMAN antibody;GR 15 antibody;GR15 antibody;IA 4 antibody;IA4 antibody;Inducible membrane protein antibody;Inducible membrane protein R2 antibody;KAI 1 antibody;KAI1 antibody;Kangai 1;suppression of tumorigenicity 6;prostate;CD82 antigen;R2 leukocyte antigen;antigen detected by monoclonal and antibody IA4;antibody;Kangai 1 antibody;Kangai1 antibody;Leukocyte surface antigen R2 antibody;Metastasis suppressor Kangai 1 antibody;Metastasis suppressor Kangai-1 antibody;Metastasis suppressor Kangai1 antibody;Prostate cancer antimetastasis gene KAI1 antibody;R2 antibody;R2 leukocyte antigen antibody;SAR 2 antibody;SAR2 antibody;ST 6 antibody;ST6 antibody;Suppression of tumorigenicity 6 antibody;Suppression of tumorigenicity 6 prostate antibody;Suppressor of tumorigenicity 6 antibody;Suppressor of tumorigenicity 6 protein antibody;Tetraspanin 27 antibody;Tetraspanin-27 antibody;Tetraspanin27 antibody;Tspan 27 antibody;Tspan-27 antibody;Tspan27 antibody;CD82 nanobody;
背景：
domain:Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM).This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.,function:Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).,online information:Siglec-3,PTM:Phosphorylation of Tyr-340 is involved in binding to PTPN6 and PTPN11. Phosphorylation of Tyr-358 is involved in binding to PTPN6.,similarity:Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Interacts with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation.,tissue specificity:Monocytic/myeloid lineage cells.,
细胞定位 ： [Isoform CD33M]: Cell membrane ; Single-pass type I membrane protein.; [Isoform CD33m]: Peroxisome . CD33m isoform does not localize to cell surfaces but instead accumulates in peroxisomes. .
推荐产品
相关文献
我们始终开放沟通，期待为您提供支持。
我们以一抗、二抗产品为核心，深耕抗体试剂细分领域。依托自主搭建的核心技术平台与专业的研发生产团队，我们为全球高校、科研院所、生物医药企业等客户提供高可靠性的生物试剂产品及全链条技术
支持服务。自成立以来，Pinofibio 始终坚守“以科研需求为导向”的发展理念，通过完善的研发体系、严苛的质量控制与高效的服务响应，致力于构建覆盖多物种、多靶点的抗体产品矩阵，助力科研工作者攻克技术难题，推动生物医药产业的创新发展。
武汉市皮诺飞生物科技有限公司
地址：湖北省武汉市江夏区神墩四路 666 号武汉国英种业大厦A栋14F
邮箱：pinuofei2017@163.com
TEL：15392937510
小红书
实验服务
公众号
抗体服务
微信客服