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货号: PD2421
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
所属分类：
靶点: SIRP-α1/β1
应用： WB,IHC,IF,ELISA
反应性 ： Human,Rat,Mouse,
宿主物种 ： Rabbit
MW(Observed)： 55kD
同种型-Isotype ： IgG
隐藏域元素占位
详细信息
推荐稀释比 ： WB 1:500-1:2000;IHC: 1:100-1:300;ELISA 1:10000;IF 1:50-200
组成 ： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 ： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 ： -15°C to -25°C/1 year(Do not lower than -25°C
浓度 ： 1 mg/ml
克隆性 ： Polyclonal
抗原&靶点信息
特异性 ： SIRP-α1/β1 Polyclonal Antibody detects endogenous levels of SIRP-α1/β1 protein.
基因名称 ： SIRPA/SIRPB1
蛋白名称 ： Tyrosine-protein phosphatase non-receptor type substrate 1/Signal-regulatory protein beta-1 isoform 3
别名 ： SIRPA;BIT;MFR;MYD1;PTPNS1;SHPS1;SIRP;Tyrosine-protein phosphatase non-receptor type substrate 1;SHP substrate 1;SHPS-1;Brain Ig-like molecule with tyrosine-based activation motifs;Bit;CD172 antigen-like family member A;Inhibitory receptor SHPS-1;Macrophage fusion receptor;MyD-1 antigen;Signal-regulatory protein alpha-1;Sirp-alpha-1;Signal-regulatory protein alpha-2;Sirp-alpha-2;Signal-regulatory protein alpha-3;Sirp-alpha-3;p84;CD172a;SIRPB1;Signal-regulatory protein beta-1 isoform 3;SIRP-beta-1 isoform 3
数据库链接：
背景：
The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternati
细胞定位 ： Membrane; Single-pass type I membrane protein.
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