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DUOX1 rabbit pAb

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说明书下载
货号: PD1292
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
+

所属分类:


靶点: DUOX1
应用: WB
反应性 : Human,Rat
宿主物种 : Rabbit
MW(CalcμLated) : 171kD
同种型-Isotype : IgG

隐藏域元素占位

详细信息

推荐稀释比 : WB 1:500-2000
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Polyclonal

抗原&靶点信息

特异性 : This antibody detects endogenous levels of DUOX1 at Human/Rat
基因名称 : DUOX1 DUOX LNOX1 THOX1
蛋白名称 : DUOX1

数据库链接:

Organism

基因 ID

SwissProt

背景:

The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2012],

细胞定位 : Apical cell membrane ; Multi-pass membrane protein . Localizes to the apical membrane of epithelial cells.

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