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AMPKβ2 Mouse mAb(Mix-mA)

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说明书下载
货号: PH0781
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
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靶点: AMPKβ2
应用: IHC,WB
反应性 : Human,Mouse,Rat
宿主物种 : Mouse
MW(Observed): 30kD

隐藏域元素占位

详细信息

推荐稀释比 : IHC1:50-200;WB 1:1000-2000
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Monoclonal

抗原&靶点信息

特异性 : This antibody detects endogenous levels of AMPKβ2 at Human, Mouse,Rat
基因名称 : PRKAB2
蛋白名称 : 5'-AMP-activated protein kinase subunit beta-2
别名 : PRKAB2;5'-AMP-activated protein kinase subunit beta-2;AMPK subunit beta-2

数据库链接:

Organism

基因 ID

SwissProt

背景:

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013],

细胞定位 : nucleoplasm,cytosol,nucleotide-activated protein kinase complex,

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