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货号: PL0864
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
所属分类：
靶点: MLKL
应用： WB,IF,ELISA
反应性 ： Human,Mouse,Rat
宿主物种 ： Rabbit
MW(CalcμLated) ： 54kD
MW(Observed)： 54kD
同种型-Isotype ： IgG,Kappa
偶联-Conjugate ： Phospho
隐藏域元素占位
详细信息
修饰-Modification ： Ser345
推荐稀释比 ： WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
组成 ： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺 ： Protein A
储存 ： -15°C to -25°C/1 year(Do not lower than -25°C
克隆性 ： Monoclonal
克隆号 ： PT0987R
抗原&靶点信息
特异性 ： MLKL (Phospho Ser345) Monoclonal Antibody detects endogenous levels of MLKL Phospho-ser345 at Human, Mouse,Rat.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):QNsIS
基因名称 ： MLKL
蛋白名称 ： MLKL Phospho-ser345
别名 ： Mixed lineage kinase domain-like protein
背景：
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015],
细胞定位 ： Cytoplasm . Cell membrane . Nucleus . Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction (PubMed:24316671). Localizes to the nucleus in response to orthomyxoviruses infection (By similarity). .
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