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推荐稀释比 ： ELISA 1:5000-100000;Flow Cyt 1-2μg/Test
组成 ： Phosphate-buffered solution
来源 ： Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell
纯化工艺 ： Recombinant Expression and Affinity purified
储存 ： -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
浓度 ： Please check the information on the tube
克隆性 ： Monoclonal
克隆号 ： PN0580
抗原&靶点信息
特异性 ： This recombinant monoclonal antibody can detects endogenous levels of CD8 protein.
基因名称 ： CD8A MAL
蛋白名称 ： Natural cytotoxicity triggering receptor 3 (Activating natural killer receptor p30) (Natural killer cell p30-related protein) (NK-p30) (NKp30) (CD antigen CD337)
别名 ： 1C7 antibody;Activating natural killer receptor p30 antibody;Activating NK A1 receptor antibody;CD337 antibody;CD337 antigen antibody;LY117 antibody;Lymphocyte antigen 117 antibody;MALS antibody;Natural cytotoxicity triggering receptor 3 antibody;Natural killer cell p30 related protein antibody;Natural killer cell p30-related protein antibody;Ncr3 antibody;NCTR3_HUMAN antibody;NK-p30 antibody;NKp30 antibody;CD337 nanobody;
背景：
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains.This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found forThis gene. [provided by RefSeq, Nov 2011]
细胞定位 ： [Isoform 1]: Cell membrane ; Single-pass type I membrane protein. CD8A localizes to lipid rafts only when associated with its partner CD8B. .; [Isoform 2]: Secreted .
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