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货号: PH1222
货期: 一周
价格: 100μL/2200
靶点: LCK
应用： WB
反应性 ： Human
宿主物种 ： Mouse
MW(Observed)： 58kD
隐藏域元素占位
详细信息
推荐稀释比 ： WB 1:1000
组成 ： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 ： The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
储存 ： -15°C to -25°C/1 year(Do not lower than -25°C
克隆性 ： Monoclonal
抗原&靶点信息
特异性 ： This antibody detects endogenous levels of LCK and does not cross-react with related proteins.
基因名称 ： lck
别名 ： LCK;Lck p56;LCK_HUMAN;Leukocyte C-terminal Src kinase;LSK;Lymphocyte cell specific protein tyrosine kinase;Lymphocyte cell-specific protein-tyrosine kinase;Lymphocyte Specific Protein Tyrosine Kinase;Membrane associated protein tyrosine kinase;Oncogene lck;P56 LCK;p56;LSTRA;protein tyrosine kinase;p56-LCK;p56lck;pp58 lck;pp58lck;Protein YT16;Proto oncogene tyrosine protein kinase LCK;Proto-oncogene Lck;Protooncogene tyrosine protein kinase LCK;T cell specific protein tyrosine kinase;T cell-specific protein-tyrosine kinase;T lymphocyte specific protein tyrosine kinase p56lck;Tyrosine-protein kinase Lck;YT 16;YT16.
背景：
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Aug 2016],
细胞定位 ： Cell membrane ; Lipid-anchor ; Cytoplasmic side . Cytoplasm, cytosol . Present in lipid rafts in an inactive form. .
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