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货号: PH1439
货期: 一周
价格: 100μL/2200
所属分类:
靶点: Stat6
应用: WB,IF,ELISA
反应性 : Human,Mouse,Rat,Monkey
宿主物种 : Mouse
MW(CalcμLated) : 94kD
隐藏域元素占位
详细信息
推荐稀释比 : WB 1:500-1:2000;IF 1:200-1:1000;ELISA 1:10000;Not yet tested in other applications.
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : Affinity purification
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
克隆性 : Monoclonal
抗原&靶点信息
特异性 : Stat6 Monoclonal Antibody detects endogenous levels of Stat6 protein.
基因名称 : STAT6
蛋白名称 : Signal transducer and activator of transcription 6
别名 : STAT6;Signal transducer and activator of transcription 6;IL-4 Stat
背景:
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010],


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