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货号: PF0432
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
靶点: TAB2
应用： WB
反应性 ： Human,Mouse,Rat
宿主物种 ： Rabbit
MW(Observed)： 77kD
同种型-Isotype ： IgG
隐藏域元素占位
详细信息
修饰-Modification ： Phospho
推荐稀释比 ： WB 1:1000-2000
组成 ： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 ： The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存 ： -15°C to -25°C/1 year(Do not lower than -25°C
浓度 ： 1 mg/ml
克隆性 ： Polyclonal
抗原&靶点信息
特异性 ： This antibody detects endogenous levels of Human Mouse Rat TAB2 (phospho-Ser372)
基因名称 ： TAB2 KIAA0733 MAP3K7IP2
蛋白名称 ： TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
别名 ： TAB2;KIAA0733;MAP3K7IP2;TGF-beta-activated kinase 1 and MAP3K7-binding protein 2;Mitogen-activated protein kinase kinase kinase 7-interacting protein 2;TAK1-binding protein 2;TAB-2;TGF-beta-activated kinase 1-binding protein 2
背景：
The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014],
细胞定位 ： Membrane ; Peripheral membrane protein . Endosome membrane ; Peripheral membrane protein . Lysosome membrane ; Peripheral membrane protein . Cytoplasm, cytosol . Following IL1 stimulation, translocation occurs from the membrane to cytosol (PubMed:10882101). Interaction with TRIM38 promotes translocation from cytosol to endosome and lysosome (PubMed:24434549). .
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