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货号: PH0540
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
靶点: CD40
应用: Flow Cyt,ELISA
反应性 : Human
宿主物种 : Mouse
MW(Observed): 30kD
同种型-Isotype : IgG1,Kappa
隐藏域元素占位
详细信息
推荐稀释比 : ELISA 1:5000-100000;Flow Cyt 1-2μg/Test
组成 : Phosphate-buffered solution
纯化工艺 : Recombinant Expression and Affinity purified
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : Please check the information on the tube
克隆性 : Monoclonal
克隆号 : PTR1379
抗原&靶点信息
特异性 : This recombinant monoclonal antibody can detects endogenous levels of CD40 protein.
基因名称 : CD40
蛋白名称 : Tumor necrosis factor receptor superfamily member 5
别名 : CD40;TNFRSF5;Tumor necrosis factor receptor superfamily member 5;B-cell surface antigen CD40;Bp50;CD40L receptor;CDw40;CD antigen CD40
背景:
This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIG


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