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货号: PH0659
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
靶点: Collagen I
应用: IF,IHC
反应性 : Human,Mouse,Rat
宿主物种 : Mouse
MW(Observed): 139kD
隐藏域元素占位
详细信息
推荐稀释比 : IF 1:50-200;IHC 1:50-300
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Monoclonal
克隆号 : 4H10
抗原&靶点信息
特异性 : The antibody detects endogenous Collagen I protein
基因名称 : COL1A1
蛋白名称 : Collagen alpha-1(I) chain (Alpha-1 type I collagen)
别名 : Collagen alpha-1;I;chain;Alpha-1 type I collagen;
数据库链接:
背景:
This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008],


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