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推荐稀释比 : IHC 1:200-1000;WB 1:500-2000;IF 1:100-500;ELISA 1:1000-5000
组成 : PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺 : Protein G
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
克隆性 : Monoclonal
克隆号 : ABT-p27
抗原&靶点信息
特异性 : This antibody detects endogenous levels of p27Kip1 protein.
基因名称 : CDKN1B KIP1
蛋白名称 : Cyclin-dependent kinase inhibitor 1B
别名 : CDKN1B;KIP1;Cyclin-dependent kinase inhibitor 1B;Cyclin-dependent kinase inhibitor p27;p27Kip1
背景:
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014],


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