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货号: PK0111
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
所属分类：
靶点: Notch 4
应用： WB,ELISA
反应性 ： Human,Monkey
宿主物种 ： Rabbit
MW(Observed)： 60kD,220kD
同种型-Isotype ： IgG
隐藏域元素占位
详细信息
推荐稀释比 ： WB 1:1000-2000;ELISA 1:5000-20000
组成 ： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 ： The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存 ： -15°C to -25°C/1 year(Do not lower than -25°C
浓度 ： 1 mg/ml
克隆性 ： Polyclonal
抗原&靶点信息
特异性 ： This antibody detects endogenous levels of Human,Monkey NOTCH4 (Cleaved-Val1467, protein was cleaved amino acid sequence between 1466-1467 )
基因名称 ： NOTCH4 INT3
蛋白名称 ： NOTCH4 (Cleaved-Val1467)
别名 ： NOTCH4;INT3;Neurogenic locus notch homolog protein 4;Notch 4;hNotch4;[Cleaved into: Notch 4 extracellular truncation;Notch 4 intracellular domain]
背景：
notch 4(NOTCH4) Homo sapiens This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor may play a role in vascular, renal and hepatic development. Mutations in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants, at least one of which
细胞定位 ： Cell membrane; Single-pass type I membrane protein.; [Notch 4 intracellular domain]: Nucleus. Following proteolytical processing NICD is translocated to the nucleus.
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