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Crk II Monoclonal Antibody

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说明书下载
货号: PH1387
货期: 一周
价格: 100μL/2200
+

详细信息

推荐稀释比 : WB 1:1000-1:2000;Not yet tested in other applications.
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : Affinity purification
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
克隆性 : Monoclonal

抗原&靶点信息

特异性 : Crk II Monoclonal Antibody detects endogenous levels of Crk II protein.
基因名称 : CRK
蛋白名称 : Adapter molecule crk
别名 : CRK;Adapter molecule crk;Proto-oncogene c-Crk;p38

数据库链接:

Organism

基因 ID

SwissProt

背景:

This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008],

细胞定位 : Cytoplasm . Cell membrane . Translocated to the plasma membrane upon cell adhesion. .

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