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货号: PH1387
货期: 一周
价格: 100μL/2200
靶点: Crk II
应用: WB
反应性 : Human,Mouse,Dog,Rabbit
宿主物种 : Mouse
MW(CalcμLated) : 34kD
隐藏域元素占位
详细信息
推荐稀释比 : WB 1:1000-1:2000;Not yet tested in other applications.
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : Affinity purification
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
克隆性 : Monoclonal
抗原&靶点信息
特异性 : Crk II Monoclonal Antibody detects endogenous levels of Crk II protein.
基因名称 : CRK
蛋白名称 : Adapter molecule crk
别名 : CRK;Adapter molecule crk;Proto-oncogene c-Crk;p38
背景:
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008],


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