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推荐稀释比 ： ELISA 1:5000-100000
组成 ： Phosphate-buffered solution
来源 ： Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell
纯化工艺 ： Recombinant Expression and Affinity purified
储存 ： -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
浓度 ： Please check the information on the tube
克隆性 ： Monoclonal
克隆号 ： PN0606
抗原&靶点信息
特异性 ： This recombinant monoclonal antibody can detects endogenous levels of HER2 protein.
基因名称 ： ERBB2
蛋白名称 ： Cytokine receptor common subunit beta (CDw131) (GM-CSF/IL-3/IL-5 receptor common beta subunit) (CD antigen CD131)
别名 ： IL-3R common β chain;CDw131;Beta-C antibody;CD131 antibody;CDw131 antibody;Colony stimulating factor 2 receptor beta antibody;Colony stimulating factor 2 receptor beta low affinity;granulocyte macrophage;antibody;Common beta chain antibody;Csf2rb antibody;Cytokine receptor common beta chain antibody;Cytokine receptor common beta chain precursor;CDw131 antigen;antibody;Cytokine receptor common subunit beta antibody;GM CSF/IL 3/IL 5 receptor common beta chain antibody;GM-CSF/IL-3/IL-5 receptor common beta subunit antibody;granulocyte-macrophage colony-stimulating factor receptor;beta antibody;IL3RB antibody;IL3RB_HUMAN antibody;IL5RB antibody;Interleukin 3 receptor;beta antibody;Interleukin 3 receptor/granulocyte macrophage colony stimulating factor 3 receptor beta;high affinity;antibody;Interleukin 5 receptor;beta antibody;SMDP5 antibody;stimulating factor 3 receptor;beta;high affinity;antibody;
背景：
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding d
细胞定位 ： [Isoform 1]: Cell membrane ; Single-pass type I membrane protein. Early endosome . Cytoplasm, perinuclear region. Nucleus. Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1. Also detected in VPS35-positive endosome-to-TGN retrograde vesicles (PubMed:31138794). .; [Isoform 2]: Cytoplasm. Nucleus.; [Isoform 3]: Cytoplasm. Nucleus.
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