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货号: PH0737
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
靶点: Caspase-3
应用: IF,WB,IP,IHC
反应性 : Human,Mouse,Rat,Chicken
宿主物种 : Mouse
MW(Observed): 17kD
隐藏域元素占位
详细信息
推荐稀释比 : IF 1:50-200;WB 1:500-1000;IHC 1:100-200
组成 : PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
纯化工艺 : The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
克隆性 : Monoclonal
克隆号 : 5E1
抗原&靶点信息
特异性 : The antibody detects endogenous cleaved Caspase-3 protein p17 isoform.
基因名称 : CASP3
蛋白名称 : Caspase3
别名 : CASP3;CPP32;Caspase-3;CASP-3;Apopain;Cysteine protease CPP32;CPP-32;Protein Yama;SREBP cleavage activity 1;SCA-1
背景:
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008],


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