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RhoA (Phospho Ser188) rabbit pAb

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说明书下载
货号: PF0391
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
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靶点: RhoA
应用: WB,ELISA,IHC
反应性 : Human,Mouse,Rat
宿主物种 : Rabbit
MW(Observed): 22kD
同种型-Isotype : IgG

隐藏域元素占位

详细信息

修饰-Modification : Phospho
推荐稀释比 : WB 1:500-2000;IHC 1:50-300;ELISA 1:2000-20000
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Polyclonal

抗原&靶点信息

特异性 : This antibody detects endogenous levels of Human,Mouse,Rat RhoA (Phospho Ser188)
基因名称 : RHOA ARH12 ARHA RHO12
蛋白名称 : RhoA (Phospho Ser188)
别名 : Transforming protein RhoA;Rho cDNA clone 12;h12;

数据库链接:

Organism

基因 ID

SwissProt

背景:

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015],

细胞定位 : Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton. Cleavage furrow. Cytoplasm, cell cortex . Midbody. Cell projection, lamellipodium . Cell projection, dendrite . Nucleus . Localized to cell-cell contacts in calcium-treated keratinocytes (By similarity). Translocates to the equatorial region before furrow formation in a ECT2-dependent manner. Localizes to the equatorial cell cortex (at the site of the presumptive furrow) in early anaphase in an activated form and in a myosin- and actin-independent manner. .

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