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货号: PF0145
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
靶点: Atm
应用: IHC,WB
反应性 : Human,Mouse
宿主物种 : Rabbit
MW(Observed): 350kD
隐藏域元素占位
详细信息
修饰-Modification : Phospho
推荐稀释比 : WB 1:500-2000;IHC 1:50-200
组成 : PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺 : The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Polyclonal
抗原&靶点信息
特异性 : This antibody detects endogenous levels of ATM (Phospho Ser183) Rabbit pAb at Human, Mouse
基因名称 : ATM
蛋白名称 : Serine-protein kinase ATM (Ataxia telangiectasia mutated) (A-T mutated)
别名 : Serine-protein kinase ATM;Ataxia telangiectasia mutated;A-T mutated;
背景:
ATM serine/threonine kinase(ATM) Homo sapiens The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010],


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