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货号: PH1812
货期: 一周
价格: 100μL/2200
所属分类:
靶点: Bmi-1
应用: WB,IHC,IF,Flow Cyt,ELISA
反应性 : Human
宿主物种 : Mouse
MW(CalcμLated) : 37kD
隐藏域元素占位
详细信息
推荐稀释比 : WB 1:500-1:2000;IHC 1:200-1:1000;IF 1:200-1:1000;Flow Cyt 1:200-1:400;ELISA 1:10000;Not yet tested in other applications.
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : Affinity purification
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
克隆性 : Monoclonal
抗原&靶点信息
特异性 : Bmi-1 Monoclonal Antibody detects endogenous levels of Bmi-1 protein.
基因名称 : BMI1
蛋白名称 : Polycomb complex protein BMI-1
别名 : BMI1;PCGF4;RNF51;Polycomb complex protein BMI-1;Polycomb group RING finger protein 4;RING finger protein 51
背景:
BMI1 proto-oncogene, polycomb ring finger(BMI1) Homo sapiens This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. [provided by RefSeq, Sep 2015],


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