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货号: PH1405
货期: 一周
价格: 100μL/2200
靶点: Wnt-1
应用： WB,IHC,IF,Flow Cyt,ELISA
反应性 ： Human,Mouse
宿主物种 ： Mouse
MW(CalcμLated) ： 41kD
隐藏域元素占位
详细信息
推荐稀释比 ： WB 1:500-1:2000;IHC 1:200-1:1000;IF 1:200-1:1000;Flow Cyt 1:200-1:400;ELISA 1:10000;Not yet tested in other applications.
组成 ： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 ： Affinity purification
储存 ： -15°C to -25°C/1 year(Do not lower than -25°C
克隆性 ： Monoclonal
抗原&靶点信息
特异性 ： Wnt-1 Monoclonal Antibody detects endogenous levels of Wnt-1 protein.
基因名称 ： WNT1
蛋白名称 ： Proto-oncogene Wnt-1
别名 ： WNT1;INT1;Proto-oncogene Wnt-1;Proto-oncogene Int-1 homolog
背景：
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in
细胞定位 ： Secreted, extracellular space, extracellular matrix . Secreted .
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