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货号: PH1265
货期: 一周
价格: 100μL/2200
靶点: Cyclin D2
应用： WB
反应性 ： Human
宿主物种 ： Mouse
MW(Observed)： 38kD
隐藏域元素占位
详细信息
推荐稀释比 ： WB 1:1000
组成 ： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 ： The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
储存 ： -15°C to -25°C/1 year(Do not lower than -25°C
克隆性 ： Monoclonal
抗原&靶点信息
特异性 ： This antibody detects over-expressed levels of Cyclin D2 and does not cross-react with related proteins.
基因名称 ： ccnd2
别名 ： CCND 2;CCND2;CCND2_HUMAN;CyclinD2;G1/S specific cyclin D2;G1/S-specific cyclin-D2;KIAK0002;MGC102758.
背景：
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencep
细胞定位 ： Nucleus . Cytoplasm . Nucleus membrane . Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members. .; [Isoform 2]: Cytoplasm .
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