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Presenilin 2 rabbit pAb

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说明书下载
货号: PD0400
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
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靶点: Presenilin 2
应用: WB,IHC
反应性 : Human,Mouse,Rat
宿主物种 : Rabbit
MW(CalcμLated) : 49kD
同种型-Isotype : IgG

隐藏域元素占位

详细信息

推荐稀释比 : WB 1:500-2000;IHC 1:50-300
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Polyclonal

抗原&靶点信息

特异性 : This antibody detects endogenous levels of Human,Mouse,Rat Presenilin 2
基因名称 : PSEN2 AD4 PS2 PSNL2 STM2
蛋白名称 : Presenilin 2
别名 : PSEN2;AD4;PS2;PSNL2;STM2;Presenilin-2;PS-2;AD3LP;AD5;E5-1;STM-2;[Cleaved into: Presenilin-2 NTF subunit;Presenilin-2 CTF subunit]

数据库链接:

Organism

基因 ID

SwissProt

背景:

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008],

细胞定位 : Endoplasmic reticulum membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein .

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