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推荐稀释比 ： ELISA 1:5000-100000
组成 ： Phosphate-buffered solution
来源 ： Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell
纯化工艺 ： Recombinant Expression and Affinity purified
储存 ： -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
浓度 ： Please check the information on the tube
克隆性 ： Monoclonal
克隆号 ： PN0478
抗原&靶点信息
特异性 ： This recombinant monoclonal antibody can detects endogenous levels of HER2 protein.
基因名称 ： ERBB2
蛋白名称 ： Carcinoembryonic antigen-related cell adhesion molecule 8 (CD67 antigen) (Carcinoembryonic antigen CGM6) (Non-specific cross-reacting antigen NCA-95) (CD antigen CD66b)
别名 ： Carcinoembryonic antigen CGM6 antibody;Carcinoembryonic antigen gene family member 6 antibody;Carcinoembryonic antigen related cell adhesion molecule 8 antibody;Carcinoembryonic antigen-related cell adhesion molecule 8 antibody;CD 66b antibody;CD 67 antibody;CD66b antibody;CD66b antigen antibody;CD67 antibody;CD67 antigen antibody;CEACAM 8 antibody;CEACAM8 antibody;CEAM8_HUMAN antibody;CGM 6 antibody;CGM6 antibody;NCA 95 antibody;NCA95 antibody;Non-specific cross-reacting antigen NCA-95 antibody;Nonspecific cross reacting antigen NCA 95 antibody;Nonspecific cross reacting antigen NCA95 antibody;CD66b nanobody;
背景：
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding d
细胞定位 ： [Isoform 1]: Cell membrane ; Single-pass type I membrane protein. Early endosome . Cytoplasm, perinuclear region. Nucleus. Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1. Also detected in VPS35-positive endosome-to-TGN retrograde vesicles (PubMed:31138794). .; [Isoform 2]: Cytoplasm. Nucleus.; [Isoform 3]: Cytoplasm. Nucleus.
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