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推荐稀释比 : ELISA 1:5000-100000;Flow Cyt 1-2μg/Test
组成 : Phosphate-buffered solution
来源 : Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell
纯化工艺 : Recombinant Expression and Affinity purified
储存 : -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
浓度 : Please check the information on the tube
克隆性 : Monoclonal
克隆号 : PN0131
抗原&靶点信息
特异性 : This recombinant monoclonal antibody can detects endogenous levels of CD59 protein.
基因名称 : CD59 MIC11 MIN1 MIN2 MIN3 MSK21
蛋白名称 : Natural killer cells antigen CD94 (KP43) (Killer cell lectin-like receptor subfamily D member 1) (NK cell receptor) (CD antigen CD94)
别名 : KLRD1;CD94;Natural killer cells antigen CD94;KP43;Killer cell lectin-like receptor subfamily D member 1;NK cell receptor;CD antigen CD94;CD94 nanobody;
背景:
This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction.This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly ofThis complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation.This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations inThis gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified forThis gene. [provided by RefSeq, Jul 2008]


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