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货号: PF1408
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
所属分类：
靶点: FGFR-4
应用： WB,ELISA
反应性 ： Human,Mouse,Rat
宿主物种 ： Rabbit
MW(Observed)： 90kD
同种型-Isotype ： IgG
隐藏域元素占位
详细信息
修饰-Modification ： Phospho
推荐稀释比 ： WB 1:500-1:2000;ELISA 1:10000;Not yet tested in other applications.
组成 ： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 ： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 ： -15°C to -25°C/1 year(Do not lower than -25°C
浓度 ： 1 mg/ml
克隆性 ： Polyclonal
抗原&靶点信息
特异性 ： Phospho-FGFR-4 (Y642) Polyclonal Antibody detects endogenous levels of FGFR-4 protein only when phosphorylated at Y642.
基因名称 ： FGFR4
蛋白名称 ： Fibroblast growth factor receptor 4
别名 ： FGFR4;JTK2;TKF;Fibroblast growth factor receptor 4;FGFR-4;CD antigen CD334
背景：
The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgII
细胞定位 ： Cell membrane; Single-pass type I membrane protein. Endosome. Endoplasmic reticulum. Internalized from the cell membrane to recycling endosomes, and from there back to the cell membrane.; [Isoform 2]: Secreted.; [Isoform 3]: Cytoplasm .
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