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RASL2 Polyclonal Antibody

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说明书下载
货号: PG7562
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
+

所属分类:


靶点: RASL2
应用: WB,ELISA
反应性 : Human,Mouse
宿主物种 : Rabbit
MW(Observed): 88kD
同种型-Isotype : IgG

隐藏域元素占位

详细信息

推荐稀释比 : WB 1:500-2000;ELISA 1:5000-20000
组成 : PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺 : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Polyclonal

抗原&靶点信息

特异性 : RASL2 Polyclonal Antibody detects endogenous levels of protein.
基因名称 : RASA4 CAPRI GAPL KIAA0538
蛋白名称 : Ras GTPase-activating protein 4 (Calcium-promoted Ras inactivator) (Ras p21 protein activator 4) (RasGAP-activating-like protein 2)

数据库链接:

Organism

基因 ID

SwissProt

Mouse
背景:

This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

细胞定位 : Cytoplasm, cytosol . Cell membrane ; Peripheral membrane protein . Localized to the cytosol as a result of its lack of phosphoinositide binding activity. Upon agonist-stimulated calcium mobilization, utilizes the C2A and C2B domains to associate with the plasma membrane.

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