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SGK3 (Phospho Thr320) rabbit pAb

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说明书下载
货号: PF0460
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
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靶点: SGK3
应用: WB,IHC
反应性 : Human,Rat,Mouse,
宿主物种 : Rabbit
MW(Observed): 54kD
同种型-Isotype : IgG

隐藏域元素占位

详细信息

修饰-Modification : Phospho
推荐稀释比 : WB 1:500-2000;IHC 1:50-300
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Polyclonal

抗原&靶点信息

特异性 : This antibody detects endogenous levels of Human SGK3 (phospho-Thr320)
基因名称 : SGK3 CISK SGKL
蛋白名称 : Serine/threonine-protein kinase Sgk3
别名 : Serine/threonine-protein kinase Sgk3;Cytokine-independent survival kinase;Serum/glucocorticoid-regulated kinase 3;Serum/glucocorticoid-regulated kinase-like;

数据库链接:

Organism

基因 ID

SwissProt

背景:

This gene is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],

细胞定位 : Cytoplasmic vesicle . Early endosome. Recycling endosome. Endosomal localization is a prerequisite for complete kinase activity. It is essential for its colocalization with the kinase responsible for phosphorylating Ser-486 thus allowing PDPK1 phosphorylation of Thr-320 resulting in complete activation of SGK3. Localized in vesicle-like structures and in the early endosome. Colocalizes with SLC9A3/NHE3 in the recycling endosomes.

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