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Mnk2 Polyclonal Antibody

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说明书下载
货号: PD4831
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
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靶点: Mnk2
应用: WB,ELISA,IHC
反应性 : Human,Mouse,Rat
宿主物种 : Rabbit
MW(Observed): 51kD
同种型-Isotype : IgG

隐藏域元素占位

详细信息

推荐稀释比 : WB 1:500-2000;IHC 1:50-300;ELISA 1:2000-20000
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Polyclonal

抗原&靶点信息

特异性 : Mnk2 Polyclonal Antibody detects endogenous levels of Mnk2 protein.
基因名称 : MKNK2
蛋白名称 : MAP kinase-interacting serine/threonine-protein kinase 2
别名 : MKNK2;GPRK7;MNK2;MAP kinase-interacting serine/threonine-protein kinase 2;MAP kinase signal-integrating kinase 2;MAPK signal-integrating kinase 2;Mnk2

数据库链接:

Organism

基因 ID

SwissProt

背景:

MAP kinase interacting serine/threonine kinase 2(MKNK2) Homo sapiens This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex.

细胞定位 : [Isoform 2]: Nucleus, PML body.; [Isoform 1]: Cytoplasm.

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