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货号: PH1360
货期: 一周
价格: 100μL/2200
所属分类：
靶点: NCAM-L1
应用： WB
反应性 ： Human,Mouse,Rat,Dog,Rabbit
宿主物种 ： Mouse
MW(CalcμLated) ： 140kD
隐藏域元素占位
详细信息
推荐稀释比 ： WB 1:1000-1:2000;Not yet tested in other applications.
组成 ： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 ： Affinity purification
储存 ： -15°C to -25°C/1 year(Do not lower than -25°C
克隆性 ： Monoclonal
抗原&靶点信息
特异性 ： NCAM-L1 Monoclonal Antibody detects endogenous levels of NCAM-L1 protein.
基因名称 ： L1CAM
蛋白名称 ： Neural cell adhesion molecule L1
别名 ： L1CAM;CAML1;MIC5;Neural cell adhesion molecule L1;N-CAM-L1;NCAM-L1;CD antigen CD171
背景：
The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of this gene results in multiple transcript variants, some of which include an alternate exon that is considered to be specific to neurons. [provided by RefSeq, May 2013],
细胞定位 ： Cell membrane ; Single-pass type I membrane protein . Cell projection, growth cone . Cell projection, axon . Cell projection, dendrite. Colocalized with SHTN1 in close apposition with actin filaments in filopodia and lamellipodia of axonalne growth cones of hippocampal neurons (By similarity). In neurons, detected predominantly in axons and cell body, weak localization to dendrites (PubMed:20621658). .
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