信号通路

联系我们

15392937510

地址:湖北省武汉市江夏区神墩四路 666 号武汉国英种业大厦A栋14F 
邮箱:pinuofei2017@163.com
TEL:15392937510

CD70 (PN0415) Nb-FC recombinant antibody

复制产品信息

说明书下载
货号: PA0280
货期: 两个月
价格: 100ug/2200
+


靶点: TIGIT
应用: ELISA
反应性 : Human

隐藏域元素占位

详细信息

推荐稀释比 : ELISA 1:5000-100000
组成 : Phosphate-buffered solution
来源 : Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell
纯化工艺 : Recombinant Expression and Affinity purified
储存 : -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
浓度 : Please check the information on the tube
克隆性 : Monoclonal
克隆号 : PN0530

抗原&靶点信息

特异性 : This recombinant monoclonal antibody can detects endogenous levels of TIGIT protein.
基因名称 : TIGIT VSIG9 VSTM3
蛋白名称 : CD70 antigen (CD27 ligand) (CD27-L) (Tumor necrosis factor ligand superfamily member 7) (CD antigen CD70)
别名 : CD70;CD27L;CD27LG;TNFSF7;CD70 antigen;CD27 ligand;CD27-L;Tumor necrosis factor ligand superfamily member 7;CD antigen CD70;CD70 nanobody;

数据库链接:

Organism

基因 ID

SwissProt

背景:

T cell immunoreceptor with Ig and ITIM domains (TIGIT), also known as VSTM3 or WUCAM, is a 26 kD, type I transmembrane protein and is a member of the PVR (poliovirus receptor) family of immunoglobulin-like domain containing proteins. TIGIT is expressed on activated T cells, follicular T helper, memory, and regulatory T cells as well as on NK cells. TIGIT is a negative regulator of NK and T cell activation. Expression of TIGIT is associated with decreased functionality of CD8 T cells in chronic viral infection and tumors. TIGIT also promotes the differentiation of tolerogenic phenotype in dendritic cells with an increased secretion of IL-10 and a diminished production of IL-12.

细胞定位 : Cell membrane ; Single-pass type I membrane protein .

推荐产品

相关文献

留言咨询

留下您想咨询的信息,我们会尽快联系您

提交