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货号: PH1655
货期: 一周
价格: 100μL/2200
靶点: GCK
应用: WB,ELISA
反应性 : Human
宿主物种 : Mouse
MW(CalcμLated) : 52kD
隐藏域元素占位
详细信息
推荐稀释比 : WB 1:500-1:2000;ELISA 1:10000;Not yet tested in other applications.
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : Affinity purification
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
克隆性 : Monoclonal
抗原&靶点信息
特异性 : GCK Monoclonal Antibody detects endogenous levels of GCK protein.
基因名称 : GCK
蛋白名称 : Glucokinase
别名 : GCK;Glucokinase;Hexokinase type IV;HK IV;Hexokinase-4;HK4;Hexokinase-D
背景:
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). [provided by RefSeq, Apr 2009],


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