信号通路

联系我们

15392937510

地址:湖北省武汉市江夏区神墩四路 666 号武汉国英种业大厦A栋14F 
邮箱:pinuofei2017@163.com
TEL:15392937510

GCK Monoclonal Antibody

复制产品信息

说明书下载
货号: PH1655
货期: 一周
价格: 100μL/2200
+


靶点: GCK
应用: WB,ELISA
反应性 : Human
宿主物种 : Mouse
MW(CalcμLated) : 52kD

隐藏域元素占位

详细信息

推荐稀释比 : WB 1:500-1:2000;ELISA 1:10000;Not yet tested in other applications.
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : Affinity purification
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
克隆性 : Monoclonal

抗原&靶点信息

特异性 : GCK Monoclonal Antibody detects endogenous levels of GCK protein.
基因名称 : GCK
蛋白名称 : Glucokinase
别名 : GCK;Glucokinase;Hexokinase type IV;HK IV;Hexokinase-4;HK4;Hexokinase-D

数据库链接:

Organism

基因 ID

SwissProt

Mouse
背景:

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). [provided by RefSeq, Apr 2009],

细胞定位 : Cytoplasm . Nucleus . Mitochondrion . Under low glucose concentrations, GCK associates with GCKR and the inactive complex is recruited to the hepatocyte nucleus. .

推荐产品

相关文献

留言咨询

留下您想咨询的信息,我们会尽快联系您

提交