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OGT (phospho Thr454) rabbit pAb

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说明书下载
货号: PF0339
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
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靶点: OGT
应用: WB,ELISA
反应性 : Human,Mouse,Rat
宿主物种 : Rabbit
MW(CalcμLated) : 115kD
同种型-Isotype : IgG

隐藏域元素占位

详细信息

修饰-Modification : Phospho
推荐稀释比 : WB 1:1000-2000;ELISA 1:5000-20000
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Polyclonal

抗原&靶点信息

特异性 : This antibody detects endogenous levels of Human,Mouse,Rat OGT (phospho Thr454)
基因名称 : OGT
蛋白名称 : OGT (phospho Thr454)
别名 : UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit;O-GlcNAc transferase subunit p110;O-linked N-acetylglucosamine transferase 110 kDa subunit;OGT;

数据库链接:

Organism

基因 ID

SwissProt

背景:

This gene encodes a glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains multiple tetratricopeptide repeats that are required for optimal recognition of substrates. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2009],

细胞定位 : Nucleus . Cytoplasm . Predominantly localizes to the nucleus. .; [Isoform 2]: Mitochondrion . Membrane . Associates with the mitochondrial inner membrane. .; [Isoform 3]: Cytoplasm . Nucleus . Cell membrane . Mitochondrion membrane . Cell projection . Mostly in the nucleus. Retained in the nucleus via interaction with HCFC1 (PubMed:21285374). After insulin induction, translocated from the nucleus to the cell membrane via phosphatidylinositide binding. Colocalizes with AKT1 at the plasma membrane. TRAK1 recruits this protein to mitochondria. In the absence of TRAK1, localizes in cytosol and nucleus (By similarity). .; [Isoform 4]: Cytoplasm. Nucleus.

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