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推荐稀释比 ： WB 1:500-2000;IHC 1:50-300;ELISA 1:2000-20000
组成 ： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 ： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 ： -15°C to -25°C/1 year(Do not lower than -25°C
浓度 ： 1 mg/ml
克隆性 ： Polyclonal
抗原&靶点信息
特异性 ： SNAT2 Polyclonal Antibody detects endogenous levels of SNAT2 protein.
基因名称 ： SLC38A2
蛋白名称 ： Sodium-coupled neutral amino acid transporter 2
别名 ： SLC38A2;ATA2;KIAA1382;SAT2;SNAT2;Sodium-coupled neutral amino acid transporter 2;Amino acid transporter A2;Protein 40-9-1;Solute carrier family 38 member 2;System A amino acid transporter 2;System A transporter 1;System N amino a
背景：
enzyme regulation:Inhibited by N-methyl-D-glucamine and probably choline.,function:Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta.,induction:Up-regulated upon hypertonic conditions and amino acid deprivation.,miscellaneous:Depletion of SCL38A2 by siRNA prevents the recovery of cells from hypertonic stress.,PTM:Polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2.,similarity:Belongs to the amino acid/polyamine transporter 2 family.,subcellular location:Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes (By similarity). Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal.,tissue specificity:Ubiquitously expressed. Widely expressed in the central nervous system with higher concentrations in caudal regions. Expressed by glutamatergic and GABAergic neurons together with astrocytes and other non-neuronal cells in the cerebral cortex (at protein level).,
细胞定位 ： Cell membrane ; Multi-pass membrane protein . Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes (By similarity). Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal. .
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