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详细信息
推荐稀释比 : WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:10000;Not yet tested in other applications.
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Polyclonal
抗原&靶点信息
特异性 : Siah-1/2 Polyclonal Antibody detects endogenous levels of Siah-1/2 protein.
基因名称 : SIAH1/SIAH2
蛋白名称 : E3 ubiquitin-protein ligase SIAH1/2
别名 : SIAH1;HUMSIAH;E3 ubiquitin-protein ligase SIAH1;Seven in absentia homolog 1;Siah-1;Siah-1a;SIAH2;E3 ubiquitin-protein ligase SIAH2;Seven in absentia homolog 2;Siah-2;hSiah2
数据库链接:
背景:
This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008],


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