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货号: PD3629
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
靶点: Sck
应用: WB,IHC
反应性 : Human,Rat
宿主物种 : Rabbit
MW(Observed): 59kD
同种型-Isotype : IgG
隐藏域元素占位
详细信息
推荐稀释比 : WB 1:500-2000;IHC 1:50-300
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Polyclonal
抗原&靶点信息
特异性 : Sck Polyclonal Antibody detects endogenous levels of Sck protein.
基因名称 : SHC2
蛋白名称 : SHC-transforming protein 2
别名 : SHC2;SCK;SHCB;SHC-transforming protein 2;Protein Sck;SHC-transforming protein B;Src homology 2 domain-containing-transforming protein C2;SH2 domain protein C2
背景:
domain:The PID domain mediates binding to the TrkA receptor.,function:Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.,miscellaneous:PubMed:15057824 has shown that SHC2 is poorly phosphorylated by the Trk receptors, in opposite to PubMed:12006576.,PTM:Phosphorylated on tyrosines by the Trk receptors.,similarity:Contains 1 PID domain.,similarity:Contains 1 SH2 domain.,subunit:Interacts with the Trk receptors in a phosphotyrosine-dependent manner and MEGF12. Once activated, binds to GRB2.,tissue specificity:Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus.,


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