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ROM-K Polyclonal Antibody

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说明书下载
货号: PD3680
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
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靶点: ROM-K
应用: WB,IHC
反应性 : Human,Mouse,Rat
宿主物种 : Rabbit
MW(CalcμLated) : 45kD
同种型-Isotype : IgG

隐藏域元素占位

详细信息

推荐稀释比 : WB 1:500-2000;IHC 1:50-300
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Polyclonal

抗原&靶点信息

特异性 : ROM-K Polyclonal Antibody detects endogenous levels of ROM-K protein.
基因名称 : KCNJ1
蛋白名称 : ATP-sensitive inward rectifier potassium channel 1
别名 : KCNJ1;ROMK1;ATP-sensitive inward rectifier potassium channel 1;ATP-regulated potassium channel ROM-K;Inward rectifier K;+;channel Kir1.1;Potassium channel;inwardly rectifying subfamily J member 1

数据库链接:

Organism

基因 ID

SwissProt

背景:

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

细胞定位 : Cell membrane ; Multi-pass membrane protein . Phosphorylation at Ser-44 by SGK1 is necessary for its expression at the cell membrane. .

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